Trimethyltin and cancer
WebJul 1, 2024 · Trimethyltin chloride (TMT) is a by-product in the synthesis of organotin, a plastic stabilizer. With the rapid development of industry, the occupational hazards caused by TMT cannot be ignored. ... Cytotoxicity in vitro of compounds has been estimated on human cancer (colon cancer HCT-116, lung carcinoma A549, breast cancer MCF-7 ... WebThe present study examined the involvement of purinergic signaling components in the rat model of hippocampal degeneration induced by trimethyltin (TMT) intoxication (8 mg/kg, single ...
Trimethyltin and cancer
Did you know?
WebMay 22, 2024 · Trimethyltin (TMT) is produced as a byproduct during this synthesis and it is more toxic than MMT and DMT. Methyltin-stabilized PVC is used in packaging, piping, coating, and window frames ( 1 ). OTs have been found to leach from PVC pipes and it can contaminate foodstuffs, beverages, drinking water, and sewage ( 3, 4 ). WebAfter injecting TMT, animals show some behavioral changes such as seizures, aggressive behavior, self-biting, impaired working memory, and hyperactivity [4]. Studies show that TMT poisoning causes...
Web17.2.4 Betaine. Betaine (trimethyl glycine) ( Figure 17.1) is a metabolite formed in the body from choline. It is a natural constituent of beets, broccoli, grains, shellfish, spinach, and … WebTrimethyltin produces a frequency-specific and dose-dependent auditory impairment. It preferentially affects the outer hair cells of the basal cochlea. Trimethyltin will produce morphologic changes in as little as 12 hours, with vacuolation of the outer hair cells visible by transmission electron microscopy.
WebDAPI染色液 (DAPI Staining Solution)是经过精心优化几乎适用于所有常见细胞和组织细胞核染色的染色液。. DAPI，即2- (4-Amidinophenyl)-6-indolecarbamidine dihydrochloride，也称DAPI dihydrochloride，分子式为C 16 H 15 N 5 ·2HCl ，分子量为350.25 ，CAS Number 28718-90-3。. DAPI是一种可以穿透细胞 ... WebApr 11, 2024 · Ginsenoside compound K has been proven to have a range of anti-cancer activities against lung cancer, leukemia, breast cancer, and colon cancer [8,9,10,11]. Ginsenoside Rh2 shows anti-cancer activity against lung cancer and liver cancer by mediating the apoptosis of cancer cells and suppressing cell proliferation and migration [ …
WebApr 6, 2024 · NiCl 2, a compound containing nickel, is extremely toxic to both humans and laboratory animals ( 1 ). Studies have shown that exposure to NiCl 2 is carcinogenic. NiCl 2 have the potential to cause cancer through various mechanisms, including oxidative stress, genomic DNA damage, epigenetic changes, and activation of transcription factors ( 2 ).
WebMay 22, 2024 · Trimethyltin was first described as a potent nephrotoxicant in two studies where this compound was orally administered in rats (28, 41). TMT induced rats to a renal … laying hens for sale onlineWebShowing 1-9 of 9 results for "trimethyltin" within Products. Products Genes Papers Technical Documents Site Content Chromatograms. Filter & Sort. All Photos (2) Trimethyltin chloride solution. Linear Formula: (CH 3) 3 SnCl. CAS No.: 1066-45-1. Molecular Weight: 199.27. Beilstein No.: 3535111. Compare Product No. Description SDS Pricing; 375187: ... kathrine tobiasenWebJun 11, 2024 · Trimethyltin (TMT) is an organotin compound that is considered a potent neurotoxicant and causes behavioral alterations as well as learning and memory impairment in mammals [5, 6]. Cognitive impairment, including memory loss and learning impairment, developed in experimental animals exposed to TMT, indicating severe hippocampal … kathrin glock net worthWebJun 16, 2010 · Trimethyltin chloride (TMTC) and triethyltin chloride (TETC) were fed to mallard (Anas platyrhynchos) ducklings for 73 to 75 d, beginning when ducklings were 3 to 4 d old. Diets were mixed to contain 0,0.5,5 or 50 ppm Sn as either TMTC or TETC. Mortality occurred only in the 5 ppm (2/5 ducklings) and 50 ppm (5/5 ducklings, all dying within 5 d) … laying hens welfare codeWebFeb 22, 2024 · Trimethyltin (TMT) is a potent neurotoxicant that affects various regions within the central nervous system, including the neocortex, cerebellum, and hippocampus. In the present study, ginsenoside Rd was investigated as a candidate neuroprotective agent in a primary hippocampal neuron culture and mouse models. TMT induced neurotoxicity in a … laying hens tractor supplyWebMalignant gliomas are the most common primary brain tumors in humans. However, poor response to conventional therapeutic approaches, including chemotherapy, leads invariably to disease recurrence and progression. The organo–tin derivative triethyltin(IV)lupinylsulfide hydrochloride (IST-FS 29) was identified and developed as potential antiproliferative agent … laying hen turkey decoyWebTrimethyltin and methyl mercury are both neurotoxicants that also have ototoxic properties. Of note is the fact that the chemically related triethyltin is a neurotoxicant but not an … kathrine switzer runs the boston marathon