Hepatic stellate cells collagen
Web1 okt. 2014 · Hepatic stellate cells (HSCs) generate matrix, which in turn may also regulate HSCs function during liver fibrosis. We hypothesized that HSCs may … Web19 jun. 2024 · Hepatic stellate cell line LX-2 were obtained from the Cell Center of Shanghai Institutes for Biological Sciences. ... Collagen-I, and TIMP-1 in LX-2 cells transfected with Sh-HLF or miR-98 mimics (Figure 5H). Our results indicated miR-98 regulates HSCs activation depending on HLF/HIF-1α signaling pathway.
Hepatic stellate cells collagen
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WebThe hepatic stellate cell (HSC) is the primary cell responsible for the dramatic increase in the synthesis of type I collagen in the cirrhotic liver. Quiescent HSCs contain a … WebThe aim of the study was the pioneering retrospective ultrastructural evaluation of respective forms of hepatic stellate cells (HSCs) and analysis of their crosstalk with other adjacent nonparenchymal cells (NPCs), especially ... They were surrounded by usually mature collagen fibers. Frequently activated KCs/MPs adhered directly to T-HSCs ...
Web11 apr. 2024 · In pathological conditions such as hepatic fibrosis or liver cirrhosis, hepatic stellate cells lose vitamin A, and synthesise a large amount of extracellular matrix components including collagen, proteoglycan, glycosaminoglycan, and … WebIn hepatic stellate cells (HSCs), FHL2 depletion caused an increased expression of TGF-β and several pro-fibrogenic matrix metalloproteinases. In summary, our study shows that …
WebHepatic fibrosis is characterized by the abnormal deposition of extracellular matrix (ECM) proteins. During hepatic fibrogenesis, hepatic stellate cell (HSC) activation followed by chronic injuries is considered a key event in fibrogenesis, and activated HSCs are known to comprise approximately 90% of ECM-producing myofibroblasts. Here, we demonstrated … WebActivation of hepatic stellate cells (HSC) is a key event in the initiation of liver fibrosis. Activated HSCs proliferate and secrete excessive amounts of extracellular matrix (ECM), …
WebThe results showed that GA significantly reduced cell density and inhibited cell proliferation and lactate levels in LX-2 cells but not in Hep-G2 cells. We found that GA prominently increased the activation of caspase-3/9 for apoptosis induction, and a pan-caspase inhibitor, Z-VAD-fmk, attenuated the cell death and apoptosis effects of GA, suggesting …
WebA contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis. download . FREE Custom List . KOL stands for Key Opinion Leader. Therapeutic areas. close . Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism. by the scruffWebDuring HSC activation, iNOS expression decreased whereas Arg1 expression increased. Inhibition of Arg1 in activated HSCs efficiently inhibited collagen production but not cell proliferation. HSC activation is accompanied by a switch of arginine catabolism from iNOS to Arg1. Inhibition of Arg1 decreases collagen synthesis. by the science guyWeb10 jul. 2012 · Objective: To investigate the effects of 18α-glycyrrhetinic acid (18α-GA) on the expression of type I and III collagen in human and rat hepatic stellate cells (HSC) and to explore the role of TGF-β1/Smad signaling pathway involved. Methods: Following 18α-GA treatment, the cell viability and cell growth were detected to determine the optimal … cloud based logistics softwareWebNuclear extracts isolated from cultured activated rat hepatic stellate cells formed four protein-DNA complexes on electrophoretic mobility shift assay with an oligonucleotide including the C/EBP binding site between -365 and -335 in the α1(I) collagen promoter. cloud based log storageWebIt may develop into hepatic cirrhosis and hepatocellular carcinoma if not controlled, which contributes to the high global morbidity and mortality rates. 1 Hepatic stellate cells (HSCs) are considered crucial in the pathogenesis of hepatic fibrosis. 2 Upon liver injuries, HSCs are transformed from their quiescent state to an activated state, … by the school busWeb20 mrt. 2024 · 2. Exosome. Exosomes are nanoscale lipid bilayer vesicles secreted by the majority of cells, ranging from 30-150 nm in diameter ().In the 1980s, exosomes were first discovered in reticulocytes and were named “Exosome” by Johnstone et al (13–16).However, for some time afterwards, exosomes were considered a way that cells … by the sea 1982 filmWeb18 jul. 2014 · Stellate cells are distributed throughout organs, where, upon chronic damage, they become activated and proliferate to secrete collagen, which results … cloud based mac