WebNov 1, 2024 · Here, we explored the role of Egr2 in the induction and maintenance of macrophage M1 and M2 polarization in the mouse in vitro and in vivo models of … WebNov 20, 2016 · EGR2, in turn, recruits histone demethylase Jarid1b resulting in demethylation of CpG island located at the miR-17–92 promoter ( 64 ). The miR17-92 …
SHIP-1 Regulates Phagocytosis and M2 Polarization …
WebPhagocytosis is a cellular process for ingesting and eliminating particles larger than 0.5 μm in diameter, including microorganisms, foreign substances, and apoptotic cells. Phagocytosis is found in many types … WebMar 21, 2024 · EGR2 (Early Growth Response 2) is a Protein Coding gene. Diseases associated with EGR2 include Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive and Charcot-Marie-Tooth … diffie–hellman key exchange protocol
Alveolar macrophages are epigenetically altered after ... - Nature
Synthetic DNA templates (gBlocks) for FLAG-tagged, wild-type EGR2, NAB2, IRF4, and PU.1 were ordered from IDT (Integrated DNA Technologies). Sequences are provided in Supplementary Table 1. Constructs were cloned into pEF6 (Invitrogen) and in vitro-transcribed (ivt) mRNA was generated as previously … See more Collection of blood cells from healthy donors was performed in compliance with the Helsinki Declaration. All donors signed an informed consent. Blood sampling, the leukapheresis procedure, and subsequent purification of … See more Transient transfections were performed using ivt mRNA (PU.1, IRF4, EGR2, NAB2) or chemically modified siRNAs (Axolabs) against … See more To measure 5-hydroxymethylcytosine (5hmC) in MO and moDC across the genome, we used the Hydroxymethyl Collector kit (Active Motif) according to the manufacturer’s … See more Genomic DNA was isolated using the DNeasy Blood and Tissue Kit (Qiagen) according to the manufacturer’s instructions. DNA … See more WebMar 18, 2024 · Here, we demonstrated macrophage phagocytosis as a key mechanism underlying the anticancer effect of therapeutic antibodies. The process is amendable by chemotherapeutic drugs such as paclitaxel, providing a potential combinatorial strategy to enhance the clinical benefit and/or overcome clinical resistance of anticancer antibodies. WebEGR2 is a known regulator of alternative activation, and was shown previously to be up-regulated in IL-4/IL-13-activated macrophages ( Jablonski et al. 2015; Veremeyko et al. 2024 ). The investigators demonstrate that Egr2 up-regulation following IL-4 stimulation is dependent on STAT6, and Egr2 expression is sustained via autoregulation. diffie hellman key exchange gfg