WebThe radiation-induced bystander effect is defined as the response of cells to the consequences of their neighbors being irradiated and has been well characterized in vitro . There is a close interrelationship between bystander responses and the abscopal responses, which occur in tissues remote from the irradiation field and this is driven by ... WebFeb 6, 2024 · The bystander effect of extracellular MMAE was observed in cocultures of Karpas 299 or Ly540 cells in presence of SGN35 with CD30 - negative Burkitt lymphoma cells (Ramos). This effect is advantageous for the treatment of HL because of the heterogeneity of its cancer cells subsets: only a small fraction is CD30 - positive [ 49 , 50 ].
Mechanism of radiation-induced bystander effect: Role of the ... - PNAS
WebOct 4, 2024 · The bystander effect, also called bystander apathy, is a term in psychology that refers to the tendency of people to take no action in an emergency situation when there are others present. This phenomenon is … WebJan 9, 2015 · We assessed the effect of apoptotic bystander cells on a T cell ELISPOT assay by selectively inducing B cell apoptosis using α-CD20 mAbs. The presence of large numbers of apoptotic B cells did not affect T cell functionality. In contrast, when PBMC were stored under unfavorable conditions, leading to damage and apoptosis in the T cells as … ari taheri md
Molecular mechanism of bystander effects and related …
WebApr 12, 2024 · In addition, several studies have revealed the bystander effect of CAR-T therapy in the clearance of antigen-negative tumor cells, which kill tumors based on the secretion of IFN-γ and the Fas/FasL pathway [49, 50]. Thus, FAP-targeted CAR-T cells are likely to attack CLDN18.2-positive tumor cells at the initial stage of treatment in our … WebMeanwhile, we further analyzed the effect of suicide gene on the bystander effect of HT29-DF cells over time. The results showed that the proliferation of HT29-DF cells was inhibited as the GCV treatment time increased compared with the control (treated with PBS) group . Effects of MSCs-DF on tumor growth WebThe co-culture analysis also suggested that the bystander effect of the ADC can dissipate over the period of time as the population of Ag+ cells declines. A novel PD model was developed to mathematically characterize the bystander effect of ADCs by combining two different cell distribution models to represent the population of Ag+ and Ag- cells ... balenciaga youtube