In medicinal chemistry, bioisosteres are chemical substituents or groups with similar physical or chemical properties which produce broadly similar biological properties in the same chemical compound. In drug design, the purpose of exchanging one bioisostere for another is to enhance … See more Classical bioisosteres Classical bioisosterism was originally formulated by James Moir and refined by Irving Langmuir as a response to the observation that different atoms with the same See more • Grimm's hydride displacement law, an early hypothesis to describe bioisosterism See more Bioisosteres of some patented compounds can be discovered automatically and used to circumvent Markush structure patent claims. It has been proposed that key force field features, that is the pharmacophore, be patented instead. See more Web抑制核糖体翻译的药物--酞丁安类 ... 大分子，导致致死合成，从而影响细胞的生长。抗代谢物的设计多采用生物电子等排原理（bioisosterism）致死性合成：是指与细胞正常代谢物结构相似的外来化合物，参与代谢过程，生成高毒性的、可导致细胞死亡的毒作用。 ...
Bioisostere - an overview ScienceDirect Topics
WebBioisosterism: A Rational Approach in Drug Design George A. Patani and Edmond J. LaVoie* Department of Pharmaceutical Chemistry, College of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08855-0789 Received May 15, 1996 (Revised Manuscript Received July 25, 1996) Contents I. Introduction 3147 II. Classical ... http://med.wanfangdata.com.cn/Paper/Detail/PeriodicalPaper_PM35086456 lattiasieni haju
University of Pittsburgh
WebA.G. Leach, ... E.J. Griffen, in Comprehensive Medicinal Chemistry III, 2024 3.10.4.2 Bioisosteres. Bioisosteres have a long history in medicinal chemistry and have been … http://www.dictall.com/indu/077/076640249C2.htm WebBioisosterism represents an approach used by the medicinal chemist for the rational modification of lead compounds into safer and more clinically effective agents. It has significant value in drug design and lead optimization process as it may enhance the desired biological or physical properties of a compound, reduce toxicity and also alter the … lattiaritilät ulkokäyttöön