2024 Adipose tissue at single-cell resolution

Adipose tissue at single-cell resolution

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August undefined, 2024

WebApr 27, 2024 · Human adipose tissue was isolated from healthy patients (patient information in Supplementary Table 1 ), dissociated into single-cell suspensions, sorted … WebApr 22, 2024 · These perivascular mesenchymal cells of the adipose tissue are critical “gatekeepers” of macrophage accumulation in obesity. ... S. Plasticity of Epididymal Adipose Tissue in Response to Diet-Induced Obesity at Single-Nucleus Resolution. Cell Metab. 2024, 33, 437–453.e435. [Google Scholar]

Adipocyte Heterogeneity Underlying Adipose Tissue Functions

WebMar 25, 2024 · Human adipose tissue cells were isolated using a previously described protocol, under ethics protocol number 2012-1308 approved by the CRCHU-de Québec-Université Laval ethics committee. Adipose-derived stem/stromal cells (ASCs) were thawed and amplified in culture according to previous studies. [ 38 ] WebApr 11, 2024 · Our experiment demonstrated that a single injection of high-dose CTX was a less damaging chemotherapeutic strategy than continuous injection of low-dose CTX, and tail-vein injection of ADSCs was a potential approach to promote the restoration of CTX-induced POF. ... Schäffler A, Büchler C. Concise review: adipose tissue-derived stromal … fornalino

Adipose-derived stem cells promote the repair of chemotherapy …

WebJun 6, 2024 · The ultimate goal of this protocol is to determine all adipose tissue subtypes under various thermogenic stimuli at a single-cell resolution. In contrast to other tissues and cell types, determining cellular subtypes of adipose tissue is challenging due to the fragility of lipid-filled adipocytes. WebMar 7, 2024 · Single-cell technologies: Promising path to resolving adipose tissue function and heterogeneity The advent of NGS-based single-cell technologies has allowed for … WebMar 7, 2024 · Adipose tissues are loose connective tissues with a high number of adipocytes. These specialized cells store metabolic energy in the form of large cytoplasmic lipid droplets and at the same time regulate several aspects of organismal physiology … diggy\u0027s adventure jarl olaf concert hall

Single cell type - EIF2B5 - The Human Protein Atlas

(PDF) Adipose tissue at single-cell resolution

WebOct 23, 2024 · Adipose tissue plays an important role in the maintenance of energy balance in mammals. A chronic imbalance between energy intake and expenditure increases adiposity and leads to obesity and predisposes to the development of metabolic disease (Rosen and Spiegelman, 2014; Wajchenberg, 2000).White adipose tissue … Webadipose tissue at a single-cell resolution and provide an extensive resource for future insights in how to target obesity.1 Obesity, characterized by excessive amounts of adipose tissue, is a condi-tion associated with elevated risk of developing metabolic diseases including cardiovascular disease, type 2diabetes,andnon-alcoholicsteatohe- fornait ggWebFeb 27, 2024 · Highlights Multidimensional transcriptome analysis at single-nucleus resolution recovers nuclei of cell types in adipose tissue Adaptative thermogenic response results in 3 distinct mature adipose cell types Single-nuclei transcriptomic-based secretome analysis reveals adipose cell-type-specific genes diggy\u0027s adventure luxor amphitheatre

"WebJun 29, 2010 · 62. Ebrahimian TG, Pouzoulet F, Squiban C, Buard V, André M, Cousin B, Gourmelon P, Benderitter M, Casteilla L, Tamarat R. Cell therapy based on adipose tissue-derived stromal cells promotes physiological and pathological wound healing. Arterioscler Thromb Vasc Biol. 2009;29:503.-510 doi: 10.1161/ATVBAHA.108.178962. " - Adipose tissue at single-cell resolution

Adipose tissue at single-cell resolution

Exercise training remodels inguinal white adipose tissue through ...

WebOct 28, 2024 · Adipose tissue is usually classified on the basis of its function as white, brown or beige (brite) 1. It is an important regulator of systemic metabolism, as shown by … WebTo identify which adipose tissue cell types are mainly responsible for ECM remodeling, ... Plasticity of epididymal adipose tissue in response to diet-induced obesity at single-nucleus resolution. Cell Metab., 33 (2024), pp. 437-453.e5. View PDF View article View in Scopus Google Scholar. 31.

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WebTwo clusters of mature adipocytes, identified through single nuclei RNA sequencing (snRNA-seq), were distinctive for proinflammatory/immune or metabolic gene expression patterns that became more transcriptionally diverse in adult animals. WebHistorically, the study of adipose tissue has been facilitated by classical techniques such as bioimaging, two-dimensional (2D) cell culture, flow cytometry, and mouse genetics. However, the increasing understanding of tissue heterogeneity and the need for more physiological in vitro models have also highlighted their limitations.

WebVAT Treg cells constitute one of the better-known specialized populations of tissue-resident Treg cells. Lean adipose tissue is rich in Treg cells that produce large amounts of IL-10 … WebOct 29, 2024 · Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. About. Single-cell analysis of human adipose tissue Resources. Readme License. MIT license Stars. 0 stars Watchers. 1 watching Forks. 0 forks Report repository Releases No releases published. Packages 0. No packages published .

WebJul 18, 2024 · Here we examine an established population of human adipose-derived stem cells (ASCs) using a novel, microfluidic-based method for high-throughput transcriptional interrogation, coupled with advanced bioinformatic analysis, to evaluate the dynamics of single cell gene expression among primary, passage 0, and passage 1 stem cells. WebJun 21, 2024 · An in-depth elucidation of the cellular alterations in subcutaneous adipose tissues of lymphedema is essential for medical development. We performed single-cell RNA sequencing of 70,209 cells of the stromal vascular fraction of adipose tissues from lymphedema patients and healthy donors.

WebMay 13, 2024 · Adipose tissue is a multicellular tissue with depot-dependent functions including safe energy storage and release, immune defense, thermogenesis, and organ padding. Emont et al. zoom in on white adipose tissue at a single-cell resolution and provide an extensive resource for future insights in how to target obesity.

WebMar 23, 2024 · Abstract. Technologies allowing studies at single-cell resolution have provided important insights into how different cell populations contribute to tissue function. Application of these methods to white adipose tissue (WAT) has revealed how various metabolic aspects of this organ, such as insulin response, inflammation and tissue … diggy\u0027s adventure marsh of madnessWebMar 7, 2024 · Summary. Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular composition under physiological and pathophysiological … fornalnational loanWebMar 7, 2024 · Adipose tissue exhibits remarkable plasticity with capacity to change in size and cellular composition under physiological and pathophysiological conditions. The … fornair extractorWebAdipose tissue is primarily comprised of large lipid-laden adipocytes, which are surrounded by various stromal vascular cells, each with a unique role. Stromal vascular cells include … fornalWebMay 13, 2024 · Adipose tissue is a multicellular tissue with depot-dependent functions including safe energy storage and release, immune defense, thermogenesis, and organ … diggy\u0027s adventure middle of the seaWebAdipose tissues display a remarkable ability to adapt to the dietary status. Here, we have applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose tissue at single-nucleus resolution in response to high-fat-diet-induced obesity. diggy\u0027s adventure marshes of despairWebAging usually comes associated with increased visceral fat accumulation, reaching even an obesity state, and favoring its associated comorbidities. One of the processes involved in … fornal memy